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If someone were to ask you what the leading cause of cancer-related death is in the US, you might guess colon cancer, breast cancer, or prostate cancer. The correct answer is actually lung cancer. It’s also the second most diagnosed cancer in the US in both men and women. Most people diagnosed with lung cancer are 65 or older. However, it can occur in younger people, too. It may also surprise you to know that up to 20% of people who die from lung cancer in the US have never smoked or used tobacco products.

It’s important to speak with your healthcare provider about any questions or concerns you may have about lung cancer, how it can be prevented, what screening tests are available, and which treatments might be right for you. Read on to learn more.

What is lung cancer?

In general, cancer happens when cells in the body grow out of control. In this case, it starts in the lungs, and is therefore called lung cancer. But when cancer cells from the lungs travel to other parts of the body, such as the lymph nodes or brain, these are called metastases.

There are 2 major types of lung cancer:

  1. Small cell. This type accounts for 15% of all lung cancers and is more aggressive than non-small cell lung cancer.
  2. Non-small cell.This is the most common type and accounts for 85% of all lung cancers. There are 3 major subtypes of non-small cell lung cancer, which include adenocarcinoma, squamous cell carcinoma, and large cell carcinoma.

Other types of lung cancer include mesothelioma and lung carcinoid.

Lung cancer

What are the causes and risks factors?

Several risk factors can increase your chances of developing lung cancer. Keep in mind that having a risk factor doesn’t mean you’ll get lung cancer.

Risk factors for lung cancer include:

In some people, having one or more of these risk factors can lead to genetic mutations in certain genes. These mutations can cause cells to divide and grow out of control, forming cancerous tumors. Some common lung cancer mutations involve the TP53, EGFR, and KRAS genes.

What are the signs and symptoms?

Each person may have different signs and symptoms. Most people may not even have any symptoms until their lung cancer is very advanced or their tumor has grown.

Lung cancer symptoms may include:

If you experience any of these symptoms, talk with your healthcare provider.

How is lung cancer diagnosed?

If your healthcare provider suspects you might have lung cancer, he or she may perform a physical exam and order certain tests. These tests may include:

Only a biopsy can confirm a lung cancer diagnosis. A biopsy is done by taking a small tissue sample from the lungs and studying it under a microscope to see if it has cancer cells. Once a diagnosis is made, other tests are run to find out if and how far the cancer has spread through the lungs, lymph nodes, and the rest of the body. This process is called staging. The stage of the cancer describes the size of the cancer, where it is and, whether it has spread. Knowing the type and stage of lung cancer helps your healthcare provider determine which treatments to use.

For people who are at high risk for developing lung cancer, screenings are recommended because they can help detect cancer early. If you have a history of heavy smoking, are currently smoking, have quit smoking within the past 15 years, and are between the ages of 55 and 80, you should speak with your healthcare provider about getting screened.

What treatments are available?

Treating lung cancer depends on which type it is, how far it has spread, and which biomarkers are found during biomarker testing. Biomarkers tell you what is inside the lung cancer cells that might be driving the tumor’s growth. Once those factors are determined, your healthcare provider can understand more about the tumor and recommend which therapies might work the best for you. Available treatments include:

Talking with your healthcare provider about any questions you may have about cancer is an important part of staying informed about your health. Download this discussion guide to help you have a more meaningful discussion with your healthcare team.



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