Vaccines are one of the greatest public health advancements of all time, resulting in the control, elimination, or near-elimination of numerous infectious diseases that were once pervasive and often fatal. Pfizer has a rich history in vaccine research and development. Over the years, we’ve played a pivotal role in eliminating or nearly eliminating deadly infectious diseases like smallpox and polio globally. We have designed novel vaccines based on new delivery systems and technologies that have resulted in vaccines to prevent bacterial infections, like those caused by S. pneumoniae and N. meningitidis.

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ONGOING VACCINE RESEARCH AND DEVELOPMENT AT PFIZER
Selected Publications from the Vaccine Research and Development Unit
- A Phase 1 First-in-Human Study (B4901001) Evaluating a Novel Anti-IgE Vaccine in Adult Subjects with Allergic RhinitisThe Journal of Allergy and Clinical ImmunologyWong GY, Elfassi E, Girard G, Yang WH, Hebert J, Bugarini R, O'Connell MA, Champion B, Merson J, Davis H.February 2016
- A Phase 1, Placebo-Controlled, Randomized Study of the Safety, Tolerability, and Immunogenicity of a Clostridium difficile Vaccine Administered With or Without Aluminum Hydroxide in Healthy AdultsVaccineSheldon E, Kitchin N, Peng Y, Eiden J, Gruber W, Johnson E, Jansen KU, Pride M, Pedneault L.April 19 2016
- A Phase 3, Randomized, Active-Controlled Study to Assess the Safety and Tolerability of Meningococcal Serogroup B Vaccine Bivalent rLP2086 in Healthy Adolescents and Young AdultsVaccineOstergaard L, Lucksinger GH, Absalon J, Beeslaar J, Eiden J, Jansen KU, York LJ, Quinn A, Graversen ME, Perez JL.March 14 2016
- A randomized phase 1 study of the safety and immunogenicity of three ascending dose levels of a 3-antigen Staphylococcus aureus vaccine (SA3Ag) in healthy adultsVaccineNissen M, Marshall H, Richmond P, Shakib S, Jiang Q, Cooper D, Rill D, Baber J, Eiden J, Gruber W, Jansen KU, Emini E, Anderson AS, Zito E, Girgenti D. April 8 2015
- Cell Surface Antigen Manganese-Binding Protein MntC from Staphylococcus aureusEncyclopedia of Inorganic and Bioinorganic ChemistryGribenko A, Liberator P, Anderson A, Matsuka Y, Mosyak L. September 14 2015
- Demonstration of the preclinical correlate of protection for Staphylococcus aureus clumping factor A in a murine model of infectionVaccineScully IL, Timofeyeva Y, Keeney D, Matsuka Y, Severina E, McNeil L, Nanra J, Hu G, Liberator PA, Jansen KU, Anderson AS.October 5 2015
- Comparison of Phenotypic and Genotypic Approaches to Capsule Typing Neisseria meningitidis Using Invasive and Carriage Strain CollectionsJournal of Clinical MicrobiologyJones HC, Mohamed N, Rojas E, Andrew L, Hoyos J, Hawkins JC, McNeil LK, Jiang Q, Mayer LW, Wang X, Gilca R, De Wals P, Pedneault L, Eiden J, Jansen KU, Anderson AS.January 2016
- Molecular attributes of conjugate antigen influence function of antibodies induced by anti-nicotine vaccine in mice and non-human primatesInternational ImmunotherapyMcCluskie MJ, Thorn J, Mehelic PR, Kolhe P, Bhattacharya K, Finneman JI, Stead DR, Bailey Piatchek M, Zhang N, Chikh G, Cartier J, Evans DM, Merson JR, Davis HLAugust 25 2015
- Optimization of Molecular Approaches to Genogroup Neisseria meningitidis Carriage Isolates and Implications for Monitoring the Impact of New Serogroup B VaccinesPLos OneRojas E, Hoyos J, Oldfield N, Lee P, Flint M, Jones CH, Ala’Aldeen D, Jansen KU, Anderson AS. July 6 2015
- Polysaccharide Conjugate Vaccine against Pneumococcal Pneumonia in AdultsThe New England Journal of MedicineBonten MJM, Huijts SM, Bolkenbaas M, Webber C, Patterson S, Gault S, van Werkhoven H, van Deursen AMM, Sanders EAM, Verheij TM, Patton M, McDonough A, Moradoghli-Haftvani A, Smith H, Mellelieu T, Pride MW, Crowther G, Schmoele-Thoma B, Scott DA, Jansen KU, Lobatto R, Oosterman, B, Visser N, Caspers E, Smorenburg A, Emini EA, Gruber WC, Grobbee DE2015
- Production and characterization of chemically inactivated genetically engineered Clostridium difficile toxoidsJournal of Pharmaceutical SciencesVidunas E, Mathews A, Zi-rong Z, Weaver M, Cai P, Koh EH, Patel-Brown S,Yuan YH, Carriere M, Johnson EJ, Lotvin J, Moran J.July 2016
- The Discovery and Development of a Novel Vaccine to Protect against Neisseria meningitidis Serogroup B DiseaseHuman VaccinesZlotnick GW, Jones TR, Liberator P, Hao L, Harris S. McNeil LK, Zhu D, Perez J, Eiden J, Jansen KU, Anderson AS.November 1 2014
Today, more people benefit from safe and efficacious vaccines to prevent infectious diseases than ever before, and vaccines provide essential health benefits at all ages, from maternal and infant populations to seniors. However, our work is not done given the many infectious diseases remaining with a high unmet medical need and a growing list of vaccine preventable diseases.
Prevention is the Best Medicine
Today is an exciting time in vaccine research and development, as scientific discoveries, technological advancements and regulatory paradigms are paving the way for novel vaccines. While Pfizer’s Vaccine Research and Development scientists continue to extend our leadership position in pneumococcal and meningococcal disease prevention, they also work on vaccines against other major infectious diseases while striving to bring the benefits of vaccines into previously unexplored areas. We are at the forefront to usher in a new era of vaccine innovation, both to prevent and treat disease, with special focus on maternal/neonatal, hospital-acquired infections (HAI), and cancer.
We are optimistic about the broad potential to bring the benefits of vaccines to every age group, protecting a person throughout his or her entire life. Our vaccine research and development efforts are focused on three areas:




Meet Some of Pfizer’s Vaccine Researchers
Nanette Cocero
Global President, Vaccines,
Pfizer Biopharmaceuticals Group
Nanette Cocero is the Global President of Pfizer Vaccines. In her role, Nanette oversees an international business and is responsible for the development and delivery of innovative vaccines that address serious and life-threatening conditions, helping to protect communities around the world.
Nanette leads a global team of 1,500 colleagues and manages a diverse vaccines portfolio aimed at protecting lives at all stages, from infants to older adults. She and her team also partner with governments, civic organizations, and others in the biopharmaceutical industry to accelerate global public health progress. She is Chair of the International Federation of Pharmaceuticals and Manufacturers Association (IFPMA) Vaccine CEO Steering Committee, advocating for policies and practices that will enable greater access and affordability to vaccines in low and middle-income countries. In addition, Nanette is a board member of the Americas Society/Council of the Americas (AS/COA).
Prior to her current position, Nanette was Regional President, Emerging Markets, for Pfizer’s Innovative Health business. In this role, she led business operations in over 100 countries across Latin America, Africa, the Middle East, and Asia, spanning Pfizer’s core therapeutic areas including vaccines, oncology, inflammation and immunology, internal medicine and rare disease. During her 15+ year tenure at Pfizer, Nanette has held numerous leadership positions in both developed and emerging markets, driving continuous growth for the businesses she managed and bringing novel medicines and access solutions to patients.
Before joining Pfizer, Nanette worked for 10 years as a management consultant and served as a Research Fellow for the University of Pennsylvania, Department of Pharmacology. Nanette earned a Bachelor of Science degree in chemistry from Cornell University; a Ph.D. in pharmacology from the University of Pennsylvania, and an MBA from The Wharton Business School. She has lived and worked in the continental United States, Puerto Rico, and Spain and she is bilingual in English and Spanish.
Kathrin Jansen, PhD
Senior Vice President,
Head of Vaccine Research and Development
Kathrin U. Jansen, PhD, is Senior Vice President and Head of Vaccine Research and Development at Pfizer Inc, and a member of Pfizer’s Worldwide Research and Development leadership team. Dr. Jansen oversees a fully integrated, global vaccines research and development organization, with responsibilities ranging from discovery to registration and post-marketing commitments of first-in-class or best-in-class vaccines to prevent or treat diseases of significant unmet medical need. More recent accomplishments are the global licensures of Prev(e)nar13® to prevent pneumococcal diseases and the development and licensure of Trumenba®, the first vaccine licensed in the United States to prevent invasive disease caused by Neisseria meningitidis serogroup B.
Dr. Jansen received her doctoral degree in microbiology, biochemistry & genetics from Phillips Universitaet, Marburg, Germany. Following completion of her formal training, she continued her postdoctoral training at Cornell University working on the structure and function of the acetylcholine receptor. She then joined the Glaxo Institute for Molecular Biology in Geneva, Switzerland, where she focused on basic studies of a receptor believed to be a drug target to treat allergies. Dr. Jansen was appointed an Adjunct Professor at the University of Pennsylvania – School of Medicine in 2010.
Before the Wyeth acquisition by Pfizer in 2009, Dr. Jansen served as Senior Vice President at Wyeth Pharmaceuticals and on Wyeth’s Research and Development Executive Committee since 2006 and was responsible for vaccine discovery, early development and clinical testing operations. Dr. Jansen also briefly worked at Vaxgen as Chief Scientific Officer and Senior Vice President for Research and Development with responsibility for the company’s late stage development programs.
Prior to joining Vaxgen, Dr. Jansen spent 12 years at Merck Research Laboratories where she directed or supported a number of vaccine efforts, including Merck’s novel bacterial vaccine programs and viral vaccine programs (rotavirus, zoster and mumps, measles and rubella). Dr. Jansen initiated and led the development of Gardasil®, the world’s first cervical cancer vaccine.
Nicholas Kitchin, MD, PhD
Senior Director
Nicholas Kitchin is Senior Director in Pfizer’s Vaccine Clinical Research and Development group. Dr. Kitchin joined Pfizer in 2011, and currently provides global medical leadership for clinical trials of the company’s investigational Clostridium difficile vaccine.
Dr. Kitchin obtained his medical degree from the University of London in 1991 and is a Fellow of the Faculty of Pharmaceutical Medicine of the Royal Colleges of Physicians of the United Kingdom.
After initial training in anaesthesiology, Dr. Kitchin joined the pharmaceutical industry in 1994, and since 1998 has specialized in the field of vaccines. Having had a wide variety of roles in this area, he is a passionate advocate for the public health benefits of vaccination.