Article

Science Fact or Science Fiction? Lactic Acid Buildup Causes Muscle Fatigue and Soreness

Anyone who has pushed themselves through an intense workout will be familiar with “feeling the burn” — that sensation of fatigue and pain that sets in when you subject your muscles to lifting heavy loads repeatedly or sprinting all-out.This burning sensation is associated with a buildup of acid in the muscles during intense exercise, and lactic acid has long been thought to be the culprit in that acid buildup, known as acidosis. Lactic acid is a byproduct of anaerobic metabolism, in which the...

A New Frontier for AI: Helping Scientists Develop Potential New Medicines

When Google’s artificial intelligence program known as AlphaGo decisively beat the reigning human champion of the ancient board game of Go in a series of high-profile matches in 2016, it was a watershed moment in the field of machine learning. And while much has been made of impressive feats of artificial intelligence (AI), like AlphaGo and self-driving cars, a lesser known fact is that the same techniques are also helping scientists explore potential new medicines. The link between AI and drug...

What’s on the Y Chromosome Handed Down From Father to Son?

Among the many things parents hand down to their children are 23 pairs of chromosomes – those thread-like structures in the nucleus of every cell containing the genetic instructions for every person. We inherit a set of 23 chromosomes from our mothers and another set of 23 from our fathers.One of those pairs are the chromosomes that determine the biological sex of a child – girls have an XX pair and boys have an XY pair, with very rare exceptions in certain disorders. Females always pass an X...

This Scientist's Life: Derek Buhl

Meet Derek Buhl, Principal Scientist for Central Nervous System (CNS) medicines at Pfizer’s Kendall Square facility in Cambridge, Mass. Buhl’s subject of research is one of the most complex systems in the known universe – the human brain, and what can go wrong with it, and how to correct problems with the help of novel pharmaceuticals. To explain what he does to a non-scientist, Buhl sometimes quotes what his 6-year-old daughter once said about his work, and how it relates to the work of his...

Bodily Functions Explained: Spicy Food Reaction

Spicy food contains chemicals that trick the body into cranking up its internal air-conditioning system, triggering responses from head to toe and involving everything from the respiratory to the circulatory system.It happens at dinner tables around the world every day. Something spicy — a chunk of chili pepper, perhaps — goes from fork to mouth, setting off a body-wide chain reaction.A burning sensation spreads across the lips and ignites the tongue. Mucous membranes, which protect the lungs...

Flashback: The First ECG

p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Times} p.p2 {margin: 5.0px 0.0px 5.0px 0.0px; font: 12.0px Times} p.p3 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Times; min-height: 14.0px} span.s1 {font: 12.0px 'Times New Roman'} Willem Einthoven found the beat and built a machine that could measure the electrical current a heart creates. It weighed 600 pounds. An electrocardiogram — called informally an ECG or EKG — measures the small electric waves that a human heart creates. It’s...

The Great Migration: Tracking Immune Cells’ Travels

Scientists are studying how immune cells move to develop better treatments for autoimmune diseases. Birds migrate. People migrate. And so do cells. T-cells squeezing between collagen fibers. PLOS ONE/Coles JA Our immune cells, in particular, are always on the move, constantly patrolling the body for foreign invaders. If an unwelcome visitor enters through the nose, mouth or eyes, or there’s a break in the skin, these nimble soldiers are ready to flood the attack site and send out signals...

advancing-medical-research

Fixing Broken Body Clocks

By finding ways to restore sleep rhythms, researchers can benefit Alzheimer’s patients and others.  Every living being from fungi to frogs has an internal clock that normally runs on a 24-hour cycle.  In humans, this master clock resides in a tiny region of the brain’s hypothalamus and controls everything from hunger and sleep patterns to daily hormone fluctuations and body temperature. The brain’s master clock sets the tempo for the rhythms of every cell throughout the whole body. “It’s like...

advancing-medical-research

3-D Molecules Move into the Fast Lane

Seeing compounds in three dimensions clears a path for making medicines faster, better. Understanding how medicines behave around human cells was once a matter of educated guesswork, in large part because how they act at the molecular level isn’t visible. But today, structural biology and computational chemistry – or the use of computer modeling and molecular dynamics simulation – take medicine design into the next dimension. Well, to be precise, the third dimension.  With the jump into 3-D...

Bodily Functions Explained: Goosebumps

A holdover from our prehistoric days, goosebumps are the end result of an adrenaline rush meant to ward off a big chill — or predators. It’s a common occurrence. A sudden freezing gust of wind or spike in air conditioning causes our hair to stand on end and our skin to prickle. If the chill is strong enough to dip your body temperature below 98.6 degrees, your skin sounds an alarm. Body muscles contract in quick bursts to generate heat and your hypothalamus triggers a rush of adrenaline. As...

This Scientist's Life: Morrie Birnbaum

Meet Morris Birnbaum, Chief Scientific Officer of Pfizer Internal Medicine, which combines the Cardiovascular/Metabolic and Neuroscience Research Units. For these two therapeutic areas, Morrie and his group are responsible for discovering the molecules and pathways that a new drug should target, as well as the clinical trials that give the first signs of evidence that a potential medicine works in the way it’s intended to. Morrie Birnbaum, Chief Scientific Officer of Pfizer Internal Medicine...

Science Fact or Science Fiction? Exercise Is Bad for Arthritis

If you type in the question “Is exercise …” in Google, the first two options that pop up are “Is exercise good for you” and then “Is exercise good for arthritis.”The fact that a question about the link between arthritis and exercise is the second-most popular search term hints at how prevalent the doubts may be about benefits of exercise for people with arthritis. And in fact, studies have shown that people with osteoarthritis and rheumatoid arthritis, exercise less than people without either...