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Exploring the Manufacturing and Testing Processes of Pharmaceuticals

When a doctor prescribes you a medicine, how does she know it could be helpful? Your doctor relies on experience, medical knowledge and training, but also on information and conclusions drawn from clinical trials. Clinical trials are research studies that test a medical intervention aimed at treating, diagnosing, or preventing a disease or health condition in human volunteers. The intervention could be a drug, a medical procedure or device, or a behavioral therapy, such as diet or exercise. Some...

Managing Sickle Cell Disease as an Adult

People with sickle cell disease (SCD) are now living longer than they did in previous decades. Doctors have a better understanding of the disease, are able to diagnose it earlier, and can more readily treat and prevent the infections the disease can cause. And thanks to new ways to treat and manage the condition, patients are now more aware of what they can do to live healthier, for longer. Still, there is currently no widely available or acceptable cure for the inherited blood disorder...

Sickle Cell Trait vs. Sickle Cell Disease

Millions of people worldwide are affected by the sickle cell blood disorder. About 100,000 people in the U.S. have sickle cell disease. It mostly affects African Americans, but it can also affect people from Hispanic, southern European, Middle Eastern and Asian Indian backgrounds.Another 2.5 million people in the U.S. have sickle cell trait (SCT). But having sickle cell trait (SCT) is not the same as having sickle cell disease (SCD).What is the difference between having sickle cell trait and...

Is It Rheumatoid Arthritis? Ask a Rheumatologist

It’s a Match! Telemedicine and a Healthier You

My parents, born in pre-war Hungary and Poland, were introduced in New York through a matchmaker. That was the custom of the times. They had a happy marriage despite the reality that the matchmaker gave incomplete and sometimes incorrect information to them and to their respective families. Their union blossomed because they used what the matchmaker provided as a starting point for deeper discussions on what mattered to them. The matchmaker's information was only the first stage in finding...

Hemophilia Q&A

Q: What is hemophilia?   A: Hemophilia is a blood disorder that primarily affects males. People who have hemophilia tend to bleed for longer periods of time following an injury or surgery. This happens because they have little, or even none, of a protein called clotting factor. Clotting factors help your blood form clots, which play an important role in stopping bleeding.    There are many of these clotting factors in the body that are needed for the blood to clot properly. People with...

Finding the Key to Alzheimer’s Dementia

I recall very vividly one of my patients who couldn’t see that his Alzheimer dementia (AD) symptoms were changing. Despite concerns from family members and his primary care doctor, this patient continued to drive. A quick brainstorm with the family led to my suggesting that they hide the car keys. Unfortunately, this caused frustration for both my patient and the caregivers. Every day he would search for the keys, going through every inch of the house and leaving a trail of disarray behind him...

What You Need to Know about Antibiotic Resistance

What is Antibiotic Resistance? Put simply, an antibiotic is a medication that will kill bacteria (or stop them from dividing) helping the body treat an infection. Antibiotic resistance occurs when an antibiotic loses its ability to stop bacterial growth and/or kill the bacteria. Because the bacteria continue to multiply despite the antibiotic, an infection can get worse even when taking an antibiotic. The more an antibiotic is used, the more likely resistance will develop. Use of an antibiotic...

What are the Gaucher Disease Symptoms

Q: What is Gaucher disease?A: Gaucher disease is a rare, inherited disease. It was first described by Dr. Philippe Gaucher in 1882 and is caused by genetic mutations (a permanent change in the DNA of a gene)  received from both parents. In people with Gaucher disease, the body’s cells do not produce enough of an enzyme called glucocerebrosidase (pronounced “GLOO-ko-SERe-bro-sy-dase”). Without enough of this enzyme, people with Gaucher disease can’t break down a fatty substance found in cells...

Living with Psoriasis: Beyond Just Skin

Psoriasis is a chronic immune mediated inflammatory disorder that affects approximately 2% of the world population or 140 million people worldwide. In the U.S, approximately 7.4 million adults have psoriasis. This chronic disease is known for its effects on the skin, which occurs when the immune system mistakenly triggers skin cells to overgrow. As a result, the life cycle of cells is sped up and an excess of them can form inflamed patches of skin that may occur anywhere on the body, especially...

Clinical Trial Practices—Safeguards in Research

If you or a loved one is considering joining a clinical trial, you may be happy to know that research studies today have strict safeguards, standards of ethics, and are highly regulated. In many cases, participating in this type of research may be one of the most closely monitored types of medical treatment available. The clinical trial process is different than it used to be, yet unfortunately the accounts and memory of practices that no longer exist may still make people uneasy about...

What You Need to Know About Sunscreen

More than 2 million people in the US are diagnosed with skin cancer every year. Unprotected skin exposed to ultraviolet (UV) radiation can also lead to several other adverse health effects, such as sunburn, premature skin aging, eye damage, and weakened immune system. The American Cancer Society states that simply staying in the shade is one of the best ways to limit exposure to UV radiation. However, if you are in the sun, it is recommended that you cover up with clothing, hat and sunglasses...